Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp73 | Bone development/growth and fracture repair | ECTS2014

S.C. injection of recombinant human parathyroid hormone rhPTH(1--84) in thigh provides a more prolonged pharmacokinetic profile and a greater calcemic response when compared with injection in abdomen

Fox John , Garceau Roger , Lagast Hjalmar

Recombinant human parathyroid hormone (rhPTH) (1–84) is currently being developed as PTH replacement therapy for patients with hypoparathyroidism. Because rhPTH(1–84) is administered subcutaneously, we compared the pharmacokinetic profile of PTH(1–84) and the calcemic response following S.C. rhPTH(1–84) injection in thigh and abdomen.In this phase 1, open-label, three-way crossover study, healthy postmenopausal women received three ra...